Coding response of an altered phenylalanine transfer RNA from an Ehrlich ascites tumor.

Phenylalanine transfer RNA (tRNA) from Ehrlich ascites tumor differs chromatographically from phenylalanine tRNA isolated from various organ sources. This paper reports studies undertaken to examine the biologic role of the altered tRNA. No differences were detected in the binding of phenylalanine tRNA from tumor or normal tissue to Escherichia coli ribosomes in the presence of synthetic polynucleotides or in the incorporation of labeled phenylalanine into protein in an in vitro system.